I had a vacation ruined a few years ago when I caught a nasty stomach virus.  Others on our flight also got sick and the only common area we had been was the airplane.  After that experience, I always carry a pack of Clorox wipes in my purse.  If I'm flying, I wipe the table tray before I use it.  When I arrive at my motel, I wipe areas such as doorknobs and TV remote.  If I rent a car, I wipe the steering wheel, door handle, etc.  I use a fresh wipe for each area I clean so that germs/bacteria will not be spread from one area to another.  When frequent hand washing isn't always possible, a quick clean with Clorox helps to eliminate sickness that could ruin a trip.  I highly recommend Clorox wipes.